It's been too long since I've posted so here are a pair of locations. These are graphics, produced by architects I've found and annotated for gaming purposes. The first was described as an electric power plant/necropolis/orchard which leads me to believe that they are handing out random tables from the 1e DMG to architecture students. I decided to stick with the program and made it an electro-ghoul factory town.
This one is the house of Pluma d'Antimore the witch. Her house is suspended from the moon by silver chains. She is known for her extravagant parties by the end of which several guests are likely to have been polymorphed into birds. The wayward sons and daughters of several very powerful and influential noble families are in her flock. Guest are transported to and from her parties by holding onto a ribbon held by one of her birds and saying a magic word which renders them weightless, allowing the bird to carry them.
this and then let them find laser guns and acquire mutations and such. I'd probably end up with some of Brendan's House Rules, but Dragonborn would be called "Sleestaks" (and have no breath weapon) and Eladrin would be "Vulkins".